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Functional, cognitive and behavioral effects of donepezil in patients with moderate Alzheimer's disease.

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Adverse Events Reported in Controlled Trials Table 4 lists adverse events that were reported in at least 2% of patients in placebo-controlled trials who received donepezil hydrochloride and for which the rate of occurrence was greater for patients treated with donepezil hydrochloride than with placebo.

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See Table 2 for a comparison of the most common adverse events following one and six week titration regimens.

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Figure 5 illustrates the cumulative percentages of patients from each of the three treatment groups who attained the measure of improvement in ADAS-cog score shown on the X axis.

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May increase gastric acid secretion; monitor closely for symptoms of active or occult GI bleeding, especially in patients at increased risk for developing ulcers (eg, history of ulcer disease, concomitant use of NSAIDs).

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The type and frequency of these adverse events were similar for both the 5 mg and 10 mg dose when using a 6 week titration.

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Although there is a lack of studies specifically investigating treatment of depression after TBI with this class of medications, the dual serotonergic and noradrenergic agents venlafaxine (Effexor, Wyeth) and duloxetine (Cymbalta, Eli Lilly) are reasonable alternative choices.

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The adverse effect rates in the paper you cited seem very high relative to what I see in the package insert and the very common statement that "donepezil is generally well tolerated" that I see in many different sources, and they are not compared to rates in the placebo group.

If you have severe liver disease, your doctor will decide if this medication is safe for you to take.

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In the United States, the Food and Drug Administration (FDA) approves medications for specific uses.

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